Synthesis and Evaluation of (99m)Tc-Labeled Dimeric Folic Acid for FR-Targeting

The folate receptor (FR) is overexpressed in a wide variety of human tumors. In our study, the multimeric concept was used to synthesize a dimeric folate derivative via a click reaction. The novel folate derivative (HYNIC-D(1)-FA(2)) was radiolabeled with (99m)Tc using tricine and trisodium tripheny...

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Detalles Bibliográficos
Autores principales: Guo, Zhide, Gao, Mengna, Song, Manli, Shi, Changrong, Zhang, Pu, Xu, Duo, You, Linyi, Zhuang, Rongqiang, Su, Xinhui, Liu, Ting, Du, Jin, Zhang, Xianzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274367/
https://www.ncbi.nlm.nih.gov/pubmed/27338334
http://dx.doi.org/10.3390/molecules21060817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274367/
https://www.ncbi.nlm.nih.gov/pubmed/27338334
http://dx.doi.org/10.3390/molecules21060817

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