Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging

Achieving a (99m)Tc labeled thymidine radiotracer for single photon emission tomography (SPECT) is considered to be of interest. In this study, four novel thymidine analogs, 6a, 6b, 6c and 6d, were successfully synthesized via “click reaction” route and then radiolabeled using a [(99m)Tc(CO)(3)](+)...

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Detalles Bibliográficos
Autores principales: Duan, Xiaojiang, Liu, Teli, Zhang, Yichun, Zhang, Junbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274394/
https://www.ncbi.nlm.nih.gov/pubmed/27104501
http://dx.doi.org/10.3390/molecules21040510
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author Duan, Xiaojiang
Liu, Teli
Zhang, Yichun
Zhang, Junbo
author_facet Duan, Xiaojiang
Liu, Teli
Zhang, Yichun
Zhang, Junbo
author_sort Duan, Xiaojiang
collection PubMed
description Achieving a (99m)Tc labeled thymidine radiotracer for single photon emission tomography (SPECT) is considered to be of interest. In this study, four novel thymidine analogs, 6a, 6b, 6c and 6d, were successfully synthesized via “click reaction” route and then radiolabeled using a [(99m)Tc(CO)(3)](+) core to prepare the corresponding (99m)Tc(CO)(3) complexes in high yields. These complexes were hydrophilic and had good in vitro stability. Biodistribution of these complexes in mice bearing S180 tumors showed that all of them exhibited accumulation in the tumors, suggesting that they would be potential tumor imaging agents.
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spelling pubmed-62743942018-12-28 Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging Duan, Xiaojiang Liu, Teli Zhang, Yichun Zhang, Junbo Molecules Article Achieving a (99m)Tc labeled thymidine radiotracer for single photon emission tomography (SPECT) is considered to be of interest. In this study, four novel thymidine analogs, 6a, 6b, 6c and 6d, were successfully synthesized via “click reaction” route and then radiolabeled using a [(99m)Tc(CO)(3)](+) core to prepare the corresponding (99m)Tc(CO)(3) complexes in high yields. These complexes were hydrophilic and had good in vitro stability. Biodistribution of these complexes in mice bearing S180 tumors showed that all of them exhibited accumulation in the tumors, suggesting that they would be potential tumor imaging agents. MDPI 2016-04-19 /pmc/articles/PMC6274394/ /pubmed/27104501 http://dx.doi.org/10.3390/molecules21040510 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Duan, Xiaojiang
Liu, Teli
Zhang, Yichun
Zhang, Junbo
Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging
title Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging
title_full Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging
title_fullStr Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging
title_full_unstemmed Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging
title_short Synthesis and Biological Evaluation of Novel (99m)Tc(CO)(3)-Labeled Thymidine Analogs as Potential Probes for Tumor Proliferation Imaging
title_sort synthesis and biological evaluation of novel (99m)tc(co)(3)-labeled thymidine analogs as potential probes for tumor proliferation imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274394/
https://www.ncbi.nlm.nih.gov/pubmed/27104501
http://dx.doi.org/10.3390/molecules21040510
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