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Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives

A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA,...

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Detalles Bibliográficos
Autores principales: Li, Yang, Feng, Ling, Song, Zhi-Fang, Li, Hai-Bei, Huai, Qi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274419/
https://www.ncbi.nlm.nih.gov/pubmed/26861280
http://dx.doi.org/10.3390/molecules21020199
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author Li, Yang
Feng, Ling
Song, Zhi-Fang
Li, Hai-Bei
Huai, Qi-Yong
author_facet Li, Yang
Feng, Ling
Song, Zhi-Fang
Li, Hai-Bei
Huai, Qi-Yong
author_sort Li, Yang
collection PubMed
description A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC(50) 1.88 ± 0.20 and 1.37 ± 0.18 μM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent.
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spelling pubmed-62744192018-12-28 Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives Li, Yang Feng, Ling Song, Zhi-Fang Li, Hai-Bei Huai, Qi-Yong Molecules Article A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC(50) 1.88 ± 0.20 and 1.37 ± 0.18 μM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent. MDPI 2016-02-06 /pmc/articles/PMC6274419/ /pubmed/26861280 http://dx.doi.org/10.3390/molecules21020199 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yang
Feng, Ling
Song, Zhi-Fang
Li, Hai-Bei
Huai, Qi-Yong
Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
title Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
title_full Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
title_fullStr Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
title_full_unstemmed Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
title_short Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
title_sort synthesis and anticancer activities of glycyrrhetinic acid derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274419/
https://www.ncbi.nlm.nih.gov/pubmed/26861280
http://dx.doi.org/10.3390/molecules21020199
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