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Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA,...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274419/ https://www.ncbi.nlm.nih.gov/pubmed/26861280 http://dx.doi.org/10.3390/molecules21020199 |
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author | Li, Yang Feng, Ling Song, Zhi-Fang Li, Hai-Bei Huai, Qi-Yong |
author_facet | Li, Yang Feng, Ling Song, Zhi-Fang Li, Hai-Bei Huai, Qi-Yong |
author_sort | Li, Yang |
collection | PubMed |
description | A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC(50) 1.88 ± 0.20 and 1.37 ± 0.18 μM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent. |
format | Online Article Text |
id | pubmed-6274419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62744192018-12-28 Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives Li, Yang Feng, Ling Song, Zhi-Fang Li, Hai-Bei Huai, Qi-Yong Molecules Article A total of forty novel glycyrrhetinic acid (GA) derivatives were designed and synthesized. The cytotoxic activity of the novel compounds was tested against two human breast cancer cell lines (MCF-7, MDA-MB-231) in vitro by the MTT method. The evaluation results revealed that, in comparison with GA, compound 42 shows the most promising anticancer activity (IC(50) 1.88 ± 0.20 and 1.37 ± 0.18 μM for MCF-7 and MDA-MB-231, respectively) and merits further exploration as a new anticancer agent. MDPI 2016-02-06 /pmc/articles/PMC6274419/ /pubmed/26861280 http://dx.doi.org/10.3390/molecules21020199 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Yang Feng, Ling Song, Zhi-Fang Li, Hai-Bei Huai, Qi-Yong Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives |
title | Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives |
title_full | Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives |
title_fullStr | Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives |
title_full_unstemmed | Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives |
title_short | Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives |
title_sort | synthesis and anticancer activities of glycyrrhetinic acid derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274419/ https://www.ncbi.nlm.nih.gov/pubmed/26861280 http://dx.doi.org/10.3390/molecules21020199 |
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