Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity

The major obstacle limiting the efficacy of current Smoothened (Smo) inhibitors is the primary and acquired resistance mainly caused by Smo mutations and Gli amplification. In this context, developing Hh inhibitors targeting Gli, the final effector of this signaling pathway, may combat the resistanc...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Huang, Wenjing, Tan, Wenfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274431/
https://www.ncbi.nlm.nih.gov/pubmed/27754442
http://dx.doi.org/10.3390/molecules21101364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274431/
https://www.ncbi.nlm.nih.gov/pubmed/27754442
http://dx.doi.org/10.3390/molecules21101364

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