Selective and Efficient Generation of ortho-Brominated para-Substituted Phenols in ACS-Grade Methanol

The mono ortho-bromination of phenolic building blocks by NBS has been achieved in short reaction times (15–20 min) using ACS-grade methanol as a solvent. The reactions can be conducted on phenol, naphthol and biphenol substrates, giving yields of >86% on gram scale. Excellent selectivity for the...

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Detalles Bibliográficos
Autores principales: Georgiev, David, Saes, Bartholomeus W. H., Johnston, Heather J., Boys, Sarah K., Healy, Alan, Hulme, Alison N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274440/
https://www.ncbi.nlm.nih.gov/pubmed/26771597
http://dx.doi.org/10.3390/molecules21010088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274440/
https://www.ncbi.nlm.nih.gov/pubmed/26771597
http://dx.doi.org/10.3390/molecules21010088

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