Design and Stereochemical Research (DFT, ECD and Crystal Structure) of Novel Bedaquiline Analogs as Potent Antituberculosis Agents

A series of bedaquiline analogs containing H-bond donors were designed as anti-Mycobacterium tuberculosis drugs. A pair of diastereoisomers (R/S- and S/S-isomers) was selected from these designed compounds for synthetic and stereochemical research. The title compounds were synthesized from chiral pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Geng, Yiding, Li, Linwei, Wu, Chengjun, Chi, Yumeng, Li, Zhen, Xu, Wei, Sun, Tiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274456/
https://www.ncbi.nlm.nih.gov/pubmed/27384553
http://dx.doi.org/10.3390/molecules21070875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274456/
https://www.ncbi.nlm.nih.gov/pubmed/27384553
http://dx.doi.org/10.3390/molecules21070875

Ejemplares similares