Synthesis of Polymer-Lipid Nanoparticles by Microfluidic Focusing for siRNA Delivery

Polyethylenimine (PEI) as a cationic polymer is commonly used as a carrier for gene delivery. PEI-800 is less toxic than PEI-25K but it is also less efficient. A novel nanocarrier was developed by combining PEI-800 with a pH-sensitive lipid to form polymer-lipid hybrid nanoparticles (P/LNPs). They w...

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Detalles Bibliográficos
Autores principales: Li, Yujing, Huang, Xueqin, Lee, Robert J., Qi, Yuhang, Wang, Kaikai, Hao, Fei, Zhang, Yu, Lu, Jiahui, Meng, Qingfan, Li, Shuai, Xie, Jing, Teng, Lesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274485/
https://www.ncbi.nlm.nih.gov/pubmed/27763492
http://dx.doi.org/10.3390/molecules21101314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274485/
https://www.ncbi.nlm.nih.gov/pubmed/27763492
http://dx.doi.org/10.3390/molecules21101314

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