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Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao

Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5–20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among...

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Detalles Bibliográficos
Autores principales: Hao, Jia, Li, Jian, Li, Xiaoxia, Liu, Yanxia, Ruan, Jingya, Dong, Yongzhe, Zhang, Yi, Wang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274520/
https://www.ncbi.nlm.nih.gov/pubmed/26999087
http://dx.doi.org/10.3390/molecules21030354
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author Hao, Jia
Li, Jian
Li, Xiaoxia
Liu, Yanxia
Ruan, Jingya
Dong, Yongzhe
Zhang, Yi
Wang, Tao
author_facet Hao, Jia
Li, Jian
Li, Xiaoxia
Liu, Yanxia
Ruan, Jingya
Dong, Yongzhe
Zhang, Yi
Wang, Tao
author_sort Hao, Jia
collection PubMed
description Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5–20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14 was obtained from the Astragalus genus for the first time, while 7–12, 18–20 were isolated from the species for the first time. The effects of the compounds obtained from the plant on glucose consumption were analyzed in differentiated L6 myotubes in vitro, whereby compounds 1, 2, 3, 7, 8, 10, 11, 14, 15 and 18 displayed significant promoting effects on glucose consumption in L6 myotubes. Among them, the activities of 1, 2 and 7 were comparable to that of insulin, which suggested that these compounds may be involved in glucose metabolism and transport.
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spelling pubmed-62745202018-12-28 Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao Hao, Jia Li, Jian Li, Xiaoxia Liu, Yanxia Ruan, Jingya Dong, Yongzhe Zhang, Yi Wang, Tao Molecules Article Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5–20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14 was obtained from the Astragalus genus for the first time, while 7–12, 18–20 were isolated from the species for the first time. The effects of the compounds obtained from the plant on glucose consumption were analyzed in differentiated L6 myotubes in vitro, whereby compounds 1, 2, 3, 7, 8, 10, 11, 14, 15 and 18 displayed significant promoting effects on glucose consumption in L6 myotubes. Among them, the activities of 1, 2 and 7 were comparable to that of insulin, which suggested that these compounds may be involved in glucose metabolism and transport. MDPI 2016-03-16 /pmc/articles/PMC6274520/ /pubmed/26999087 http://dx.doi.org/10.3390/molecules21030354 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hao, Jia
Li, Jian
Li, Xiaoxia
Liu, Yanxia
Ruan, Jingya
Dong, Yongzhe
Zhang, Yi
Wang, Tao
Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
title Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
title_full Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
title_fullStr Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
title_full_unstemmed Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
title_short Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
title_sort aromatic constituents from the stems of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274520/
https://www.ncbi.nlm.nih.gov/pubmed/26999087
http://dx.doi.org/10.3390/molecules21030354
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