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Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao
Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5–20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274520/ https://www.ncbi.nlm.nih.gov/pubmed/26999087 http://dx.doi.org/10.3390/molecules21030354 |
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author | Hao, Jia Li, Jian Li, Xiaoxia Liu, Yanxia Ruan, Jingya Dong, Yongzhe Zhang, Yi Wang, Tao |
author_facet | Hao, Jia Li, Jian Li, Xiaoxia Liu, Yanxia Ruan, Jingya Dong, Yongzhe Zhang, Yi Wang, Tao |
author_sort | Hao, Jia |
collection | PubMed |
description | Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5–20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14 was obtained from the Astragalus genus for the first time, while 7–12, 18–20 were isolated from the species for the first time. The effects of the compounds obtained from the plant on glucose consumption were analyzed in differentiated L6 myotubes in vitro, whereby compounds 1, 2, 3, 7, 8, 10, 11, 14, 15 and 18 displayed significant promoting effects on glucose consumption in L6 myotubes. Among them, the activities of 1, 2 and 7 were comparable to that of insulin, which suggested that these compounds may be involved in glucose metabolism and transport. |
format | Online Article Text |
id | pubmed-6274520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62745202018-12-28 Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao Hao, Jia Li, Jian Li, Xiaoxia Liu, Yanxia Ruan, Jingya Dong, Yongzhe Zhang, Yi Wang, Tao Molecules Article Four new aromatic constituents, astraflavonoids A (1), B (2), C (3), and astramemoside A (4), along with sixteen known ones 5–20 were obtained from the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao. Their structures were elucidated by chemical and spectroscopic methods. Among the known isolates, 14 was obtained from the Astragalus genus for the first time, while 7–12, 18–20 were isolated from the species for the first time. The effects of the compounds obtained from the plant on glucose consumption were analyzed in differentiated L6 myotubes in vitro, whereby compounds 1, 2, 3, 7, 8, 10, 11, 14, 15 and 18 displayed significant promoting effects on glucose consumption in L6 myotubes. Among them, the activities of 1, 2 and 7 were comparable to that of insulin, which suggested that these compounds may be involved in glucose metabolism and transport. MDPI 2016-03-16 /pmc/articles/PMC6274520/ /pubmed/26999087 http://dx.doi.org/10.3390/molecules21030354 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hao, Jia Li, Jian Li, Xiaoxia Liu, Yanxia Ruan, Jingya Dong, Yongzhe Zhang, Yi Wang, Tao Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao |
title | Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao |
title_full | Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao |
title_fullStr | Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao |
title_full_unstemmed | Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao |
title_short | Aromatic Constituents from the Stems of Astragalus membranaceus (Fisch.) Bge. var. Mongholicus (Bge.) Hsiao |
title_sort | aromatic constituents from the stems of astragalus membranaceus (fisch.) bge. var. mongholicus (bge.) hsiao |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274520/ https://www.ncbi.nlm.nih.gov/pubmed/26999087 http://dx.doi.org/10.3390/molecules21030354 |
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