A Computational Study of the Mechanism of Succinimide Formation in the Asn–His Sequence: Intramolecular Catalysis by the His Side Chain

The rates of deamidation reactions of asparagine (Asn) residues which occur spontaneously and nonenzymatically in peptides and proteins via the succinimide intermediate are known to be strongly dependent on the nature of the following residue on the carboxyl side (Xxx). The formation of the succinim...

Descripción completa

Detalles Bibliográficos
Autores principales: Takahashi, Ohgi, Manabe, Noriyoshi, Kirikoshi, Ryota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274526/
https://www.ncbi.nlm.nih.gov/pubmed/27005609
http://dx.doi.org/10.3390/molecules21030327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274526/
https://www.ncbi.nlm.nih.gov/pubmed/27005609
http://dx.doi.org/10.3390/molecules21030327

Ejemplares similares