Synthesis of a Morpholino Nucleic Acid (MNA)-Uridine Phosphoramidite, and Exon Skipping Using MNA/2′-O-Methyl Mixmer Antisense Oligonucleotide

In this study, we synthesised a morpholino nucleoside-uridine (MNA-U) phosphoramidite and evaluated the potential of a MNA-modified antisense oligonucleotide (AO) sequences to induce exon 23 skipping in mdx mouse myotubes in vitro towards extending the applicability of morpholino chemistry with othe...

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Detalles Bibliográficos
Autores principales: Chen, Suxiang, Le, Bao T., Rahimizadeh, Kamal, Shaikh, Khalil, Mohal, Narinder, Veedu, Rakesh N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274534/
https://www.ncbi.nlm.nih.gov/pubmed/27879669
http://dx.doi.org/10.3390/molecules21111582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274534/
https://www.ncbi.nlm.nih.gov/pubmed/27879669
http://dx.doi.org/10.3390/molecules21111582

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