Photoactivatable Caged Prodrugs of VEGFR-2 Kinase Inhibitors

In this study, we report on the design, synthesis, photokinetic properties and in vitro evaluation of photoactivatable caged prodrugs for the receptor tyrosine kinase VEGFR-2. Highly potent VEGFR-2 inhibitors 1 and 3 were caged by introduction of a photoremovable protecting group (PPG) to yield the...

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Detalles Bibliográficos
Autores principales: Pinchuk, Boris, Horbert, Rebecca, Döbber, Alexander, Kuhl, Lydia, Peifer, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274539/
https://www.ncbi.nlm.nih.gov/pubmed/27136525
http://dx.doi.org/10.3390/molecules21050570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274539/
https://www.ncbi.nlm.nih.gov/pubmed/27136525
http://dx.doi.org/10.3390/molecules21050570

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