Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade

The ubiquitin system is important for drug discovery, and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions, previously developed inhibitors have been found to bind the evolutionarily conser...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yiwei, Jiang, Yuxuan, Ding, Shan, Li, Jiawang, Song, Ningjing, Ren, Yujing, Hong, Danning, Wu, Cai, Li, Bin, Wang, Feng, He, Wei, Wang, Jiawei, Mei, Ziqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274642/
https://www.ncbi.nlm.nih.gov/pubmed/30254335
http://dx.doi.org/10.1038/s41422-018-0091-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274642/
https://www.ncbi.nlm.nih.gov/pubmed/30254335
http://dx.doi.org/10.1038/s41422-018-0091-x

Ejemplares similares