Cryo-EM reveals ligand induced allostery underlying InsP(3)R channel gating

Inositol-1,4,5-trisphosphate receptors (InsP(3)Rs) are cation channels that mobilize Ca(2+) from intracellular stores in response to a wide range of cellular stimuli. The paradigm of InsP(3)R activation is the coupled interplay between binding of InsP(3) and Ca(2+) that switches the ion conduction p...

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Detalles Bibliográficos
Autores principales: Fan, Guizhen, Baker, Mariah R., Wang, Zhao, Seryshev, Alexander B., Ludtke, Steven J., Baker, Matthew L., Serysheva, Irina I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274648/
https://www.ncbi.nlm.nih.gov/pubmed/30470765
http://dx.doi.org/10.1038/s41422-018-0108-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274648/
https://www.ncbi.nlm.nih.gov/pubmed/30470765
http://dx.doi.org/10.1038/s41422-018-0108-5

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