Ginkgolic Acid Rescues Lens Epithelial Cells from Injury Caused by Redox Regulated-Aberrant Sumoylation Signaling by Reviving Prdx6 and Sp1 Expression and Activities

Sumoylation is a downstream effector of aging/oxidative stress; excess oxidative stress leads to dysregulation of a specificity protein1 (Sp1) and its target genes, such as Peroxiredoxin 6 (Prdx6), resulting in cellular damage. To cope with oxidative stress, cells rely on a signaling pathway involvi...

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Detalles Bibliográficos
Autores principales: Chhunchha, Bhavana, Singh, Prerna, Singh, Dhirendra P., Kubo, Eri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274983/
https://www.ncbi.nlm.nih.gov/pubmed/30413111
http://dx.doi.org/10.3390/ijms19113520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274983/
https://www.ncbi.nlm.nih.gov/pubmed/30413111
http://dx.doi.org/10.3390/ijms19113520

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