Development of Inducible CD19-CAR T Cells with a Tet-On System for Controlled Activity and Enhanced Clinical Safety

The tetracycline regulatory system has been widely used to control the transgene expression. With this powerful tool, it might be possible to effectively control the functional activity of chimeric antigen receptor (CAR) T cells and manage the severe side effects after infusion. In this study, we de...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Xingjian, He, Dongyang, Li, Caixin, Wang, Hua, Yang, Guanghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275001/
https://www.ncbi.nlm.nih.gov/pubmed/30400287
http://dx.doi.org/10.3390/ijms19113455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275001/
https://www.ncbi.nlm.nih.gov/pubmed/30400287
http://dx.doi.org/10.3390/ijms19113455

Ejemplares similares