Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to the protein. This molecular mechanism is the molecular basis of anthracycline anticancer activity as well as the toxic effects su...

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Detalles Bibliográficos
Autores principales: Marinello, Jessica, Delcuratolo, Maria, Capranico, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275052/
https://www.ncbi.nlm.nih.gov/pubmed/30404148
http://dx.doi.org/10.3390/ijms19113480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275052/
https://www.ncbi.nlm.nih.gov/pubmed/30404148
http://dx.doi.org/10.3390/ijms19113480

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