Cargando…

Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives

Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to the protein. This molecular mechanism is the molecular basis of anthracycline anticancer activity as well as the toxic effects su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marinello, Jessica, Delcuratolo, Maria, Capranico, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275052/ https://www.ncbi.nlm.nih.gov/pubmed/30404148 http://dx.doi.org/10.3390/ijms19113480

Ejemplares similares

Topoisomerase I poison-triggered immune gene activation is markedly reduced in human small-cell lung cancers by impairment of the cGAS/STING pathway
por: Marinello, Jessica, et al.
Publicado: (2022)

Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening
por: Drwal, Malgorzata N., et al.
Publicado: (2014)

Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation
por: Marinello, Jessica, et al.
Publicado: (2013)

Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters
por: Marinello, Jessica, et al.
Publicado: (2016)

DNA Topoisomerase I differentially modulates R-loops across the human genome
por: Manzo, Stefano G., et al.
Publicado: (2018)

Ligands stimulating antitumour immunity as the next G-quadruplex challenge
por: Miglietta, Giulia, et al.
Publicado: (2022)

Menogaril, an Anthracycline Derivative, Inhibits DNA Topoisomerase II by Stabilizing Cleavable Complexes
por: Ono, Katsuhiro, et al.
Publicado: (1992)

Catalytic Inhibitors of Topoisomerase II Differently Modulate the Toxicity of Anthracyclines in Cardiac and Cancer Cells
por: Vavrova, Anna, et al.
Publicado: (2013)

Natural Products as Topoisomerase II Poisons: Effects of Thymoquinone on DNA Cleavage Mediated by Human Topoisomerase IIα
por: Ashley, Rachel E., et al.
Publicado: (2014)

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1α gene locus
por: Baranello, Laura, et al.
Publicado: (2010)

Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy
por: Mehta, Amol, et al.
Publicado: (2018)

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
por: Hawtin, Rachael E., et al.
Publicado: (2010)

Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy
por: Yue, Jingyin, et al.
Publicado: (2012)

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ
por: Smith, Nicholas A., et al.
Publicado: (2014)

Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells
por: More, Piyush, et al.
Publicado: (2019)

BCL-2, topoisomerase IIα, microvessel density and prognosis of early advanced breast cancer patients after adjuvant anthracycline-based chemotherapy
por: Biesaga, Beata, et al.
Publicado: (2014)

Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage
por: Barker, Catherine R., et al.
Publicado: (2006)

The ATP-dependent chromatin remodelling enzyme Uls1 prevents Topoisomerase II poisoning
por: Swanston, Amy, et al.
Publicado: (2019)

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
por: Cowell, Ian G., et al.
Publicado: (2019)

Molecular mechanism of topoisomerase poisoning by the peptide antibiotic albicidin
por: Michalczyk, Elizabeth, et al.
Publicado: (2023)

Molecular pathogenetic mechanisms and new therapeutic perspectives in anthracycline-induced cardiomyopathy
por: Distefano, Giuseppe
Publicado: (2009)

Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer
por: Susini, Tommaso, et al.
Publicado: (2014)

Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity
por: Bavlovič Piskáčková, Hana, et al.
Publicado: (2021)

Topoisomerase II α Gene alteration in Triple Negative Breast Cancer and Its Predictive Role for Anthracycline-Based Chemotherapy (Egyptian NCI Patients)
por: Eltohamy, Mahitab Ibrahim, et al.
Publicado: (2018)

The Roles of DNA Topoisomerase IIβ in Transcription
por: Madabhushi, Ram
Publicado: (2018)

Targeting DNA Topoisomerase II in Antifungal Chemotherapy
por: Kondaka, Kavya, et al.
Publicado: (2022)

Lycobetaine acts as a selective topoisomerase IIβ poison and inhibits the growth of human tumour cells
por: Barthelmes, H U, et al.
Publicado: (2001)

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons
por: Zdraljevic, Stefan, et al.
Publicado: (2017)

Tuning the surface coating of IONs toward efficient sonochemical tethering and sustained liberation of topoisomerase II poisons
por: Michalkova, Hana, et al.
Publicado: (2019)

Topoisomerase 2 alpha as a predictor of response to anthracycline neoadjuvant chemotherapy in locally advanced breast cancer
por: Shehata, M, et al.
Publicado: (2010)

Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin
por: D'Annessa, Ilda, et al.
Publicado: (2012)

DNA-PK triggers histone ubiquitination and signaling in response to DNA double-strand breaks produced during the repair of transcription-blocking topoisomerase I lesions
por: Cristini, Agnese, et al.
Publicado: (2016)

NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells
por: Wu, Szu-Ying, et al.
Publicado: (2014)

Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation
por: Huang, Nan-Lan, et al.
Publicado: (2015)

Targeting of Chk2 as a countermeasure to dose-limiting toxicity triggered by topoisomerase-II (TOP2) poisons
por: Gokare, Prashanth, et al.
Publicado: (2016)

Tuning the Surface Coating of IONs Toward Efficient Sonochemical Tethering and Sustained Liberation of Topoisomerase II Poisons [Corrigendum]
Publicado: (2021)

ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms
por: Shu, Jianfeng, et al.
Publicado: (2023)

Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor
por: Cheng, Bokun, et al.
Publicado: (2013)

Anthracyclines in the treatment of early breast cancer friend or foe?
por: Vuger, Ana Tecic, et al.
Publicado: (2022)

Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
por: Arencibia, Jose M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dcet0r700mk35mo2cula9bl7nm