Cargando…

Renal Cell Carcinoma (RCC) Tumors Display Large Expansion of Double Positive (DP) CD4+CD8+ T Cells With Expression of Exhaustion Markers

Checkpoint inhibitors target the inhibitory receptors expressed by tumor-infiltrating T cells in order to reinvigorate an anti-tumor immune response. Therefore, understanding T cell composition and phenotype in human tumors is crucial. We analyzed by flow cytometry tumor-infiltrating lymphocytes (TI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Menard, Laurence C., Fischer, Paul, Kakrecha, Bijal, Linsley, Peter S., Wambre, Erik, Liu, Maochang C., Rust, Blake J., Lee, Deborah, Penhallow, Becky, Manjarrez Orduno, Nataly, Nadler, Steven G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275222/ https://www.ncbi.nlm.nih.gov/pubmed/30534127 http://dx.doi.org/10.3389/fimmu.2018.02728

Ejemplares similares

Double Positive CD4(+)CD8(+) (DP) T-Cells Display Distinct Exhaustion Phenotype in Chronic Hepatitis C
por: Kochanowicz, Anna Maria, et al.
Publicado: (2023)

Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer
por: Manjarrez-Orduño, Nataly, et al.
Publicado: (2018)

Radiation combines with immune checkpoint blockade to enhance T cell priming in a murine model of poorly immunogenic pancreatic cancer
por: Stump, Courtney T., et al.
Publicado: (2021)

CD8(+) T Cell Exhaustion in Cancer
por: Dolina, Joseph S., et al.
Publicado: (2021)

Exhausted-like CD8(+) T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects
por: Diggins, Kirsten E., et al.
Publicado: (2021)

CD39 Expression Identifies Terminally Exhausted CD8(+) T Cells
por: Gupta, Prakash K., et al.
Publicado: (2015)

CD44 Is Associated with Poor Prognosis of ccRCC and Facilitates ccRCC Cell Migration and Invasion through HAS1/MMP9
por: Du, Tan, et al.
Publicado: (2023)

Fundamentals to therapeutics: Epigenetic modulation of CD8(+) T Cell exhaustion in the tumor microenvironment
por: Blake, Maja K., et al.
Publicado: (2023)

Responders to low-dose ATG induce CD4(+) T cell exhaustion in type 1 diabetes
por: Jacobsen, Laura M., et al.
Publicado: (2023)

CD146 as a Prognostic-Related Biomarker in ccRCC Correlating With Immune Infiltrates
por: Lv, Zheng, et al.
Publicado: (2021)

Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D
por: Linsley, Peter S., et al.
Publicado: (2019)

CD8 Cells of Patients with Diffuse Cutaneous Leishmaniasis Display Functional Exhaustion: The Latter Is Reversed, In Vitro, by TLR2 Agonists
por: Hernández-Ruiz, Joselín, et al.
Publicado: (2010)

SLE risk alleles and cell development and activation
por: Kim, SJ, et al.
Publicado: (2012)

Severely ill COVID-19 patients display impaired exhaustion features in SARS-CoV-2-reactive CD8(+) T cells
por: Kusnadi, Anthony, et al.
Publicado: (2021)

P031: CD4+ T cells in close proximity to Hodgkin-Reed Sternberg cells are antigen experienced, polyclonal and display an exhausted phenotype
por: Veldman, Johanna, et al.
Publicado: (2022)

Expression of RSK4, CD44 and MMP-9 is upregulated and positively correlated in metastatic ccRCC
por: Ma, Jing, et al.
Publicado: (2020)

CD103+ Tissue Resident T-Lymphocytes Accumulate in Lung Metastases and Are Correlated with Poor Prognosis in ccRCC
por: Sanders, Christine, et al.
Publicado: (2022)

CD38 marks the exhausted CD8(+) tissue-resident memory T cells in hepatocellular carcinoma
por: Reolo, Marie J. Y., et al.
Publicado: (2023)

Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells Contributed to T Cell Exhaustion in Colorectal Cancer
por: Hu, Jiaqi, et al.
Publicado: (2021)

Accumulation of exhausted CD8+ T cells in extramammary Paget’s disease
por: Iga, Natsuko, et al.
Publicado: (2019)

Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma
por: Rad Pour, Soudabeh, et al.
Publicado: (2019)

TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion
por: Khan, Omar, et al.
Publicado: (2019)

Downregulation of CD73 associates with T cell exhaustion in AML patients
por: Kong, Yaxian, et al.
Publicado: (2019)

Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion
por: Busselaar, Julia, et al.
Publicado: (2020)

Skeletal muscle antagonizes antiviral CD8(+) T cell exhaustion
por: Wu, Jingxia, et al.
Publicado: (2020)

Activation or exhaustion of CD8(+) T cells in patients with COVID-19
por: Rha, Min-Seok, et al.
Publicado: (2021)

Filarial Lymphedema Patients Are Characterized by Exhausted CD4(+) T Cells
por: Horn, Sacha, et al.
Publicado: (2022)

Transcriptional regulatory network for the establishment of CD8(+) T cell exhaustion
por: Seo, Wooseok, et al.
Publicado: (2021)

Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells
por: Bannoud, Nadia, et al.
Publicado: (2021)

Sex‐bias in CD8 (+) T‐cell stemness and exhaustion in cancer
por: Hussain, Tabinda, et al.
Publicado: (2022)

Strategies to reinvigorate exhausted CD8(+) T cells in tumor microenvironment
por: Guan, Qianting, et al.
Publicado: (2023)

Landscapes and mechanisms of CD8(+) T cell exhaustion in gastrointestinal cancer
por: Ding, Jia-Tong, et al.
Publicado: (2023)

Regulation of CD8(+) T memory and exhaustion by the mTOR signals
por: Chen, Yao, et al.
Publicado: (2023)

CD83 expression characterizes precursor exhausted T cell population
por: Wu, Zhiwen, et al.
Publicado: (2023)

Development of a novel human phage display-derived anti-LAG3 scFv antibody targeting CD8(+) T lymphocyte exhaustion
por: Ascione, Alessandro, et al.
Publicado: (2019)

CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2013)

Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8(+) T cell exhaustion
por: Ma, Kaili, et al.
Publicado: (2022)

Metal-specific CD4(+) T cell responses induced by beryllium exposure in HLA-DP2 transgenic mice
por: Falta, Michael T., et al.
Publicado: (2015)

Overexpression CPT1A reduces lipid accumulation via PPARα/CD36 axis to suppress the cell proliferation in ccRCC: CPT1A inhibits ccRCC cell proliferation via PPARα/CD36 axis
por: Yang, Hui, et al.
Publicado: (2021)

Comprehensive immunophenotyping of solid tumor-infiltrating immune cells reveals the expression characteristics of LAG-3 and its ligands
por: Garman, Bradley, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_l1rvjq39qob94jh7btll0fn32n