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Relationship between intact HIV-1 proviruses in circulating CD4(+) T cells and rebound viruses emerging during treatment interruption

Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented by a variety of methods, most prominently by...

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Detalles Bibliográficos
Autores principales: Lu, Ching-Lan, Pai, Joy A., Nogueira, Lilian, Mendoza, Pilar, Gruell, Henning, Oliveira, Thiago Y., Barton, John, Lorenzi, Julio C. C., Cohen, Yehuda Z., Cohn, Lillian B., Klein, Florian, Caskey, Marina, Nussenzweig, Michel C., Jankovic, Mila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275529/
https://www.ncbi.nlm.nih.gov/pubmed/30420517
http://dx.doi.org/10.1073/pnas.1813512115