Chronic increases in sphingosine kinase-1 activity induce a pro-inflammatory, pro-angiogenic phenotype in endothelial cells

Sphingosine kinase-1 (SK1) promotes the formation of sphingosine-1-phosphate (S1P), which has potent pro-inflammatory and pro-angiogenic effects. We investigated the effects of raised SK1 levels on endothelial cell function and the possibility that this signaling pathway is activated in rheumatoid a...

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Detalles Bibliográficos
Autores principales: Limaye, Vidya, Xia, Pu, Hahn, Chris, Smith, Malcolm, Vadas, Mathew A., Pitson, Stuart M., Gamble, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275620/
https://www.ncbi.nlm.nih.gov/pubmed/19238330
http://dx.doi.org/10.2478/s11658-009-0009-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275620/
https://www.ncbi.nlm.nih.gov/pubmed/19238330
http://dx.doi.org/10.2478/s11658-009-0009-1

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