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Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes
A clear association between obesity and heart failure exists and a significant role for leptin, the product of the obese gene, has been suggested. One aspect of myocardial remodeling which characterizes heart failure is a disruption in the balance of extracellular matrix synthesis and degradation. H...
Autores principales: | Schram, Kristin, De Girolamo, Sabrina, Madani, Siham, Munoz, Diana, Thong, Farah, Sweeney, Gary |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SP Versita
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275652/ https://www.ncbi.nlm.nih.gov/pubmed/20683677 http://dx.doi.org/10.2478/s11658-010-0027-z |
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