The Allosteric Site on SHP2’s Protein Tyrosine Phosphatase Domain is Targetable with Druglike Small Molecules

[Image: see text] Difficulties in developing active-site-directed protein tyrosine phosphatase (PTP) inhibitors have led to the perception that PTPs are “undruggable”, highlighting the need for new means to target pharmaceutically important PTPs allosterically. Recently, we characterized an alloster...

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Detalles Bibliográficos
Autores principales: Marsh-Armstrong, Brennan, Fajnzylber, Jesse M., Korntner, Samuel, Plaman, Bailey A., Bishop, Anthony C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275946/
https://www.ncbi.nlm.nih.gov/pubmed/30533581
http://dx.doi.org/10.1021/acsomega.8b02200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275946/
https://www.ncbi.nlm.nih.gov/pubmed/30533581
http://dx.doi.org/10.1021/acsomega.8b02200

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