The Beta-Arrestin-Biased Dopamine D(2) Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation

BACKGROUND: Previous evidence suggests that UNC9994 is a beta-arrestin2-selective agonist at the dopamine D(2) receptor, lacking ability both to activate and antagonize G protein-dependent signaling. However, this has only been reported by one laboratory using a single assay. METHODS: We used G prot...

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Detalles Bibliográficos
Autores principales: Ågren, Richard, Århem, Peter, Nilsson, Johanna, Sahlholm, Kristoffer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276031/
https://www.ncbi.nlm.nih.gov/pubmed/29986044
http://dx.doi.org/10.1093/ijnp/pyy059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276031/
https://www.ncbi.nlm.nih.gov/pubmed/29986044
http://dx.doi.org/10.1093/ijnp/pyy059

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