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Comparing Hydrogen Deuterium Exchange and Fast Photochemical Oxidation of Proteins: a Structural Characterisation of Wild-Type and ΔN6 β(2)-Microglobulin

Hydrogen deuterium exchange (HDX) coupled to mass spectrometry (MS) is a well-established technique employed in the field of structural MS to probe the solvent accessibility, dynamics and hydrogen bonding of backbone amides in proteins. By contrast, fast photochemical oxidation of proteins (FPOP) us...

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Detalles Bibliográficos
Autores principales: Cornwell, Owen, Radford, Sheena E., Ashcroft, Alison E., Ault, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276068/
https://www.ncbi.nlm.nih.gov/pubmed/30267362
http://dx.doi.org/10.1007/s13361-018-2067-y