Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity

The role of small heterodimer partner (SHP) in regulation of xenobiotic detoxification remains elusive. Here, we uncover a critical role for SHP in circadian regulation of cytochromes P450 (CYPs) and drug-induced hepatotoxicity. Methods: The mRNA and protein levels of CYPs in the livers of wild-type...

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Detalles Bibliográficos
Autores principales: Zhang, Tianpeng, Yu, Fangjun, Guo, Lianxia, Chen, Min, Yuan, Xue, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276094/
https://www.ncbi.nlm.nih.gov/pubmed/30555544
http://dx.doi.org/10.7150/thno.28676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276094/
https://www.ncbi.nlm.nih.gov/pubmed/30555544
http://dx.doi.org/10.7150/thno.28676

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