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Targeting Mitochondrial Dysfunction and Oxidative Stress in Activated Microglia using Dendrimer-Based Therapeutics

Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to translate into clinical success due to their nonspecific cellular localization, poor transport properties across mu...

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Detalles Bibliográficos
Autores principales: Sharma, Anjali, Liaw, Kevin, Sharma, Rishi, Zhang, Zhi, Kannan, Sujatha, Kannan, Rangaramanujam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276292/
https://www.ncbi.nlm.nih.gov/pubmed/30555562
http://dx.doi.org/10.7150/thno.29039