Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9

Recombinant adeno-associated virus serotype 9 (rAAV9) can specifically transduce muscle and neuronal tissues; thus, rAAV9 can potentially be used in gene therapy. However, rAAV9 is the most challenging rAAV serotype to purify. Traditionally, rAAV9 has been purified by ultracentrifugation, which is n...

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Detalles Bibliográficos
Autores principales: Tomono, Taro, Hirai, Yukihiko, Okada, Hironori, Miyagawa, Yoshitaka, Adachi, Kumi, Sakamoto, Shuhei, Kawano, Yasuhiro, Chono, Hideto, Mineno, Junichi, Ishii, Akiko, Shimada, Takashi, Onodera, Masafumi, Tamaoka, Akira, Okada, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276309/
https://www.ncbi.nlm.nih.gov/pubmed/30533449
http://dx.doi.org/10.1016/j.omtm.2018.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276309/
https://www.ncbi.nlm.nih.gov/pubmed/30533449
http://dx.doi.org/10.1016/j.omtm.2018.10.015

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