The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities

Polyglutamine (polyQ) repeat diseases are a class of neurodegenerative disorders caused by CAG-repeat expansion. There are diverse cellular mechanisms behind the pathogenesis of polyQ disorders, including transcriptional dysregulation. Interestingly, we find that levels of the long isoform of nuclea...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Congsheng, Spengler, Ryan M, Keiser, Megan S, Monteys, Alejandro Mas, Rieders, Julianne M, Ramachandran, Shyam, Davidson, Beverly L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276831/
https://www.ncbi.nlm.nih.gov/pubmed/30239724
http://dx.doi.org/10.1093/hmg/ddy331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276831/
https://www.ncbi.nlm.nih.gov/pubmed/30239724
http://dx.doi.org/10.1093/hmg/ddy331

Ejemplares similares