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The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities
Polyglutamine (polyQ) repeat diseases are a class of neurodegenerative disorders caused by CAG-repeat expansion. There are diverse cellular mechanisms behind the pathogenesis of polyQ disorders, including transcriptional dysregulation. Interestingly, we find that levels of the long isoform of nuclea...
Autores principales: | Cheng, Congsheng, Spengler, Ryan M, Keiser, Megan S, Monteys, Alejandro Mas, Rieders, Julianne M, Ramachandran, Shyam, Davidson, Beverly L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276831/ https://www.ncbi.nlm.nih.gov/pubmed/30239724 http://dx.doi.org/10.1093/hmg/ddy331 |
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