Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness

The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 an...

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Autores principales: Xia, Ji-Han, Wei, Gong-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276850/
https://www.ncbi.nlm.nih.gov/pubmed/30525094
http://dx.doi.org/10.1080/23723556.2018.1516451
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author Xia, Ji-Han
Wei, Gong-Hong
author_facet Xia, Ji-Han
Wei, Gong-Hong
author_sort Xia, Ji-Han
collection PubMed
description The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness.
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spelling pubmed-62768502019-09-20 Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness Xia, Ji-Han Wei, Gong-Hong Mol Cell Oncol Author’s Views The 19q13 allele rs11672691 has been reproducibly found in association with aggressive form of prostate cancer, yet the underlying mechanism remains totally unknown. We have recently uncovered a mechanism by which rs11672691 influenced a novel oncogenic regulatory circuit, including HOXA2, PCAT19 and CEACAM21, thereby contributing to prostate cancer aggressiveness. Taylor & Francis 2018-09-20 /pmc/articles/PMC6276850/ /pubmed/30525094 http://dx.doi.org/10.1080/23723556.2018.1516451 Text en © 2018 The Author(s). Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Xia, Ji-Han
Wei, Gong-Hong
Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
title Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
title_full Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
title_fullStr Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
title_full_unstemmed Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
title_short Oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
title_sort oncogenic regulatory circuits driven by 19q13 rs11672691 underlies prostate cancer aggressiveness
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276850/
https://www.ncbi.nlm.nih.gov/pubmed/30525094
http://dx.doi.org/10.1080/23723556.2018.1516451
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