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Breaking bad family ties: Pan-ERBB blockers inhibit KRAS driven lung tumorigenesis
Oncogenic K-RAS mutations were believed to lock the molecular switch in the ON state, independent of upstream activation. However, we demonstrate in preclinical models that activity of mutated K-RAS depends on upstream signaling events involving EGF receptor family members. This finding reveals a po...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276852/ https://www.ncbi.nlm.nih.gov/pubmed/30525091 http://dx.doi.org/10.1080/23723556.2018.1513724 |