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ESR1 fusions drive endocrine therapy resistance and metastasis in breast cancer

Estrogen receptor alpha gene (ESR1) fusion transcripts have been identified in breast cancer but their role in breast cancer is not completely understood. Here, we report a causal role for ESR1 fusions in driving both endocrine therapy resistance and metastasis, and describe a therapeutic strategy t...

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Detalles Bibliográficos
Autores principales: Lei, Jonathan T., Gou, Xuxu, Ellis, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276858/
https://www.ncbi.nlm.nih.gov/pubmed/30525098
http://dx.doi.org/10.1080/23723556.2018.1526005