Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early‐onset Parkinson's disease. Parkin is autoinhibited but is activated by the kinase PINK1 that phosphorylates ubiquitin leading to parkin recruitment, and stimulates phosphoryla...

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Detalles Bibliográficos
Autores principales: Condos, Tara EC, Dunkerley, Karen M, Freeman, E Aisha, Barber, Kathryn R, Aguirre, Jacob D, Chaugule, Viduth K, Xiao, Yiming, Konermann, Lars, Walden, Helen, Shaw, Gary S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276879/
https://www.ncbi.nlm.nih.gov/pubmed/30446597
http://dx.doi.org/10.15252/embj.2018100014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276879/
https://www.ncbi.nlm.nih.gov/pubmed/30446597
http://dx.doi.org/10.15252/embj.2018100014

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