Cargando…

Aberrant splicing in B-cell acute lymphoblastic leukemia

Mostrar otras versiones (1)

Aberrant splicing is a hallmark of leukemias with mutations in splicing factor (SF)-encoding genes. Here we investigated its prevalence in pediatric B-cell acute lymphoblastic leukemias (B-ALL), where SFs are not mutated. By comparing these samples to normal pro-B cells, we found thousands of aberra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Black, Kathryn L, Naqvi, Ammar S, Asnani, Mukta, Hayer, Katharina E, Yang, Scarlett Y, Gillespie, Elisabeth, Bagashev, Asen, Pillai, Vinodh, Tasian, Sarah K, Gazzara, Matthew R, Carroll, Martin, Taylor, Deanne, Lynch, Kristen W, Barash, Yoseph, Thomas-Tikhonenko, Andrei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277088/ https://www.ncbi.nlm.nih.gov/pubmed/30357359 http://dx.doi.org/10.1093/nar/gky946

Ejemplares similares

Aberrant splicing in B-cell acute lymphoblastic leukemia
por: Black, Kathryn L, et al.
Publicado: (2019)

Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies
por: Zheng, Sisi, et al.
Publicado: (2022)

Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19
por: Asnani, Mukta, et al.
Publicado: (2019)

FBXW7β isoform drives transcriptional activation of the proinflammatory TNF cluster in human pro-B cells
por: Yang, Scarlett Y., et al.
Publicado: (2022)

Direct long-read RNA sequencing identifies a subset of questionable exitrons likely arising from reverse transcription artifacts
por: Schulz, Laura, et al.
Publicado: (2021)

Alternative splicing of its 5′-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies
por: Ang, Zhiwei, et al.
Publicado: (2023)

Integrative deep models for alternative splicing
por: Jha, Anupama, et al.
Publicado: (2017)

MAJIQ-SPEL: web-tool to interrogate classical and complex splicing variations from RNA-Seq data
por: Green, Christopher J, et al.
Publicado: (2018)

Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia
por: Loftus, Joseph P., et al.
Publicado: (2020)

Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes
por: Gazzara, Matthew R., et al.
Publicado: (2017)

Enhanced Integrated Gradients: improving interpretability of deep learning models using splicing codes as a case study
por: Jha, Anupama, et al.
Publicado: (2020)

A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers
por: Wang, David, et al.
Publicado: (2023)

A new view of transcriptome complexity and regulation through the lens of local splicing variations
por: Vaquero-Garcia, Jorge, et al.
Publicado: (2016)

Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation
por: Martinez, Nicole M., et al.
Publicado: (2015)

HGG-21. ABERRANT SPLICING OF CLK1 IN PEDIATRIC HIGH-GRADE GLIOMAS DISRUPTS KEY ONCOGENIC TRANSCRIPTIONAL PROGRAMS
por: Naqvi, Ammar, et al.
Publicado: (2023)

P1421: BIMODAL TARGETING OF CYTOKINE RECEPTOR-LIKE FACTOR 2 (CRLF2) WITH JAK INHIBITION AND CHIMERIC ANTIGEN RECEPTOR T CELL IMMUNOTHERAPY IN DOWN SYNDROME ACUTE LYMPHOBLASTIC LEUKEMIA
por: Bagashev, A., et al.
Publicado: (2022)

Identifying common transcriptome signatures of cancer by interpreting deep learning models
por: Jha, Anupama, et al.
Publicado: (2022)

Roles and functions of HIV-1 Tat protein in the CNS: an overview
por: Bagashev, Asen, et al.
Publicado: (2013)

MOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis
por: Slaff, Barry, et al.
Publicado: (2021)

RNA splicing analysis using heterogeneous and large RNA-seq datasets
por: Vaquero-Garcia, Jorge, et al.
Publicado: (2023)

Meta-analysis of transcriptomic variation in T-cell populations reveals both variable and consistent signatures of gene expression and splicing
por: Radens, Caleb M., et al.
Publicado: (2020)

TCF3::HLF acute lymphoblastic leukemia: still challenging to cure thirty years later
por: Tasian, Sarah K.
Publicado: (2023)

CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum
por: Bagashev, Asen, et al.
Publicado: (2018)

Model-based detection of alternative splicing signals
por: Barash, Yoseph, et al.
Publicado: (2010)

DIPG-31. MOLECULAR MECHANISMS AND FUNCTIONAL IMPACT OF ABERRANT SPLICING IN DIFFUSE MIDLINE GLIOMAS
por: Naqvi, Ammar, et al.
Publicado: (2020)

An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning
por: Ehrmann, Ingrid, et al.
Publicado: (2019)

Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia
por: Bongiovanni, Deborah, et al.
Publicado: (2017)

HIV-1 Tat promotes premature brain aging
por: Bagashev, Asen, et al.
Publicado: (2014)

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1
por: Closa, Adria, et al.
Publicado: (2022)

An illuminated view of molecular biology
por: Barash, Yoseph, et al.
Publicado: (2010)

Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus
por: Asnani, Mukta, et al.
Publicado: (2016)

PCBP2 enables the cadicivirus IRES to exploit the function of a conserved GRNA tetraloop to enhance ribosomal initiation complex formation
por: Asnani, Mukta, et al.
Publicado: (2016)

Alternative splicing of apoptosis genes promotes human T cell survival
por: Blake, Davia, et al.
Publicado: (2022)

High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia
por: Othman, Moneeb A. K., et al.
Publicado: (2015)

Aberrant EPHB4 gene methylation and childhood acute lymphoblastic leukemia
por: Li, Yuhua, et al.
Publicado: (2017)

Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias
por: Huang, Benjamin J., et al.
Publicado: (2019)

T-Cell Lymphoblastic Lymphoma Showing Aberrant Synaptophysin Expression in a Child
por: Koçer, Nazım Emrah, et al.
Publicado: (2020)

JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia
por: Steeghs, Elisabeth M.P., et al.
Publicado: (2017)

Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia
por: Schraw, Jeremy M., et al.
Publicado: (2018)

The Profile of Immunophenotype and Genotype Aberrations in Subsets of Pediatric T-Cell Acute Lymphoblastic Leukemia
por: Noronha, Elda Pereira, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3c7vhlio7aesvpuj6k6fjpneke