RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activation

Human bone marrow-derived mesenchymal stem cells (hBMSCs) are important for tissue regeneration but their epigenetic regulation is not well understood. Here we investigate the ability of a non-nucleoside DNA methylation inhibitor, RG108 to induce epigenetic changes at both global and gene-specific l...

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Detalles Bibliográficos
Autores principales: Assis, Rahyza I. F., Wiench, Malgorzata, Silvério, Karina G., da Silva, Rodrigo A., Feltran, Geórgia da Silva, Sallum, Enilson A., Casati, Marcio Z., Nociti, Francisco H., Andia, Denise C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277091/
https://www.ncbi.nlm.nih.gov/pubmed/30507955
http://dx.doi.org/10.1371/journal.pone.0207873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277091/
https://www.ncbi.nlm.nih.gov/pubmed/30507955
http://dx.doi.org/10.1371/journal.pone.0207873

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