Synthetic (10)FN3-based mono- and bivalent inhibitors of MDM2/X function

Engineered non-antibody scaffold proteins constitute a rapidly growing technology for diagnostics and modulation/perturbation of protein function. Here, we describe the rapid and systematic development of high-affinity (10)FN3 domain inhibitors of the MDM2 and MDMX proteins. These are often overexpr...

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Detalles Bibliográficos
Autores principales: Lau, S -Y, Siau, J W, Sobota, R M, Wang, C -I, Zhong, P, Lane, D P, Ghadessy, F J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277172/
https://www.ncbi.nlm.nih.gov/pubmed/30169723
http://dx.doi.org/10.1093/protein/gzy018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277172/
https://www.ncbi.nlm.nih.gov/pubmed/30169723
http://dx.doi.org/10.1093/protein/gzy018

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