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Synthetic (10)FN3-based mono- and bivalent inhibitors of MDM2/X function
Engineered non-antibody scaffold proteins constitute a rapidly growing technology for diagnostics and modulation/perturbation of protein function. Here, we describe the rapid and systematic development of high-affinity (10)FN3 domain inhibitors of the MDM2 and MDMX proteins. These are often overexpr...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277172/ https://www.ncbi.nlm.nih.gov/pubmed/30169723 http://dx.doi.org/10.1093/protein/gzy018 |