Lessons learned from merging wet lab experiments with molecular simulation to improve mAb humanization

Humanized monoclonal antibodies (mAbs) are among the most promising modern therapeutics, but defined engineering strategies are still not available. Antibody humanization often leads to a loss of affinity, as it is the case for our model antibody Ab2/3H6 (PDB entry 3BQU). Identifying appropriate bac...

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Detalles Bibliográficos
Autores principales: Schwaigerlehner, L, Pechlaner, M, Mayrhofer, P, Oostenbrink, C, Kunert, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277173/
https://www.ncbi.nlm.nih.gov/pubmed/29757445
http://dx.doi.org/10.1093/protein/gzy009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277173/
https://www.ncbi.nlm.nih.gov/pubmed/29757445
http://dx.doi.org/10.1093/protein/gzy009

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