Variable heavy–variable light domain and Fab-arm CrossMabs with charged residue exchanges to enforce correct light chain assembly

Technologies for the production of bispecific antibodies need to overcome two major challenges. The first one is correct heavy chain assembly, which was solved by knobs-into-holes technology or charge interactions in the CH3 domains. The second challenge is correct light chain assembly. This can be...

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Detalles Bibliográficos
Autores principales: Regula, Joerg Thomas, Imhof-Jung, Sabine, Mølhøj, Michael, Benz, Joerg, Ehler, Andreas, Bujotzek, Alexander, Schaefer, Wolfgang, Klein, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277175/
https://www.ncbi.nlm.nih.gov/pubmed/30169707
http://dx.doi.org/10.1093/protein/gzy021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277175/
https://www.ncbi.nlm.nih.gov/pubmed/30169707
http://dx.doi.org/10.1093/protein/gzy021

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