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Thermodynamic characterization for the denatured state of bovine prion protein and the BSE Associated variant E211K

Propagation of transmissible spongiform encephalopathies involves the conversion of cellular prion protein, PrP(C), into a misfolded oligomeric form, PrP(Sc). The most common hereditary prion disease is a genetic form of Creutzfeldt-Jakob disease in humans, in which a mutation in the prion gene resu...

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Detalles Bibliográficos
Autores principales: Hwang, Soyoun, Nicholson, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277186/
https://www.ncbi.nlm.nih.gov/pubmed/30354921
http://dx.doi.org/10.1080/19336896.2018.1534485