L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer’s Disease

The urea cycle is strongly implicated in the pathogenesis of Alzheimer’s disease (AD). Arginase-I (ARGI) accumulation at sites of amyloid-beta (Aβ) deposition is associated with L-arginine deprivation and neurodegeneration. An interaction between the arginase II (ARGII) and mTOR-ribosomal protein S6...

Descripción completa

Detalles Bibliográficos
Autores principales: Polis, Baruh, Srikanth, Kolluru D., Elliott, Evan, Gil-Henn, Hava, Samson, Abraham O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277292/
https://www.ncbi.nlm.nih.gov/pubmed/30288668
http://dx.doi.org/10.1007/s13311-018-0669-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277292/
https://www.ncbi.nlm.nih.gov/pubmed/30288668
http://dx.doi.org/10.1007/s13311-018-0669-5

Ejemplares similares