Cargando…

Development and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer

Here we describe the establishment and characterization of an AR+, PSMA+, ERG+, PTEN(−/−), CHD1(+/−) patient-derived xenograft (PDX) model termed ‘C5’, which has been developed from a 60 years old patient suffering from castration-resistant prostate cancer (CRPC). The patient underwent radical prost...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lange, Tobias, Oh-Hohenhorst, Su Jung, Joosse, Simon A., Pantel, Klaus, Hahn, Oliver, Gosau, Tobias, Dyshlovoy, Sergey A., Wellbrock, Jasmin, Feldhaus, Susanne, Maar, Hanna, Gehrcke, Renate, Kluth, Martina, Simon, Ronald, Schlomm, Thorsten, Huland, Hartwig, Schumacher, Udo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277427/ https://www.ncbi.nlm.nih.gov/pubmed/30510249 http://dx.doi.org/10.1038/s41598-018-35695-8

Ejemplares similares

Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases
por: Hänel, Lorena, et al.
Publicado: (2018)

CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo
por: Oh-Hohenhorst, Su Jung, et al.
Publicado: (2021)

Biology, detection, and clinical implications of circulating tumor cells
por: Joosse, Simon A, et al.
Publicado: (2015)

CEACAM1 promotes melanoma metastasis and is involved in the regulation of the EMT associated gene network in melanoma cells
por: Wicklein, Daniel, et al.
Publicado: (2018)

Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice
por: Labitzky, Vera, et al.
Publicado: (2020)

Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets
por: Spethmann, Tanja, et al.
Publicado: (2021)

Heterogeneity of ERG expression in prostate cancer: a large section mapping study of entire prostatectomy specimens from 125 patients
por: Tsourlakis, Maria-Christina, et al.
Publicado: (2016)

Role of Metastasis-Related microRNAs in Prostate Cancer Progression and Treatment
por: Oh-Hohenhorst, Su Jung, et al.
Publicado: (2021)

Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer
por: Schroeder, Cornelia, et al.
Publicado: (2019)

Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy
por: Ernst, Ann-Kathrin, et al.
Publicado: (2018)

VEGFR-1 Overexpression Identifies a Small Subgroup of Aggressive Prostate Cancers in Patients Treated by Prostatectomy
por: Tsourlakis, Maria Christina, et al.
Publicado: (2015)

Selection and Characterization of an α6β4 Integrin blocking DNA Aptamer
por: Berg, Katharina, et al.
Publicado: (2016)

PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer
por: Heinrich, Marie-Christine, et al.
Publicado: (2018)

Upregulation of centromere protein F is linked to aggressive prostate cancers
por: Göbel, Cosima, et al.
Publicado: (2018)

Subcellular Compartmentalization of Survivin is Associated with Biological Aggressiveness and Prognosis in Prostate Cancer
por: Hennigs, Jan K., et al.
Publicado: (2020)

Improved Detection of Circulating Tumor Cells in Metastatic Colorectal Cancer by the Combination of the CellSearch(®) System and the AdnaTest(®)
por: Gorges, Tobias M., et al.
Publicado: (2016)

Loss of Somatostatin Receptor Subtype 2 in Prostate Cancer Is Linked to an Aggressive Cancer Phenotype, High Tumor Cell Proliferation and Predicts Early Metastatic and Biochemical Relapse
por: Hennigs, Jan K., et al.
Publicado: (2014)

High concordance of TMPRSS-ERG fusion between primary prostate cancer and its lymph node metastases
por: Brandi, Franziska, et al.
Publicado: (2018)

High mitochondria content is associated with prostate cancer disease progression
por: Grupp, Katharina, et al.
Publicado: (2013)

Deletion of 3p13 is a late event linked to progression of TMPRSS2:ERG fusion prostate cancer
por: Kluth, Martina, et al.
Publicado: (2018)

Deletion of 18q is a strong and independent prognostic feature in prostate cancer
por: Kluth, Martina, et al.
Publicado: (2016)

Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model
por: Brodbeck, Tobias, et al.
Publicado: (2014)

Identification of potential classes of glycoligands mediating dynamic endothelial adhesion of human tumor cells
por: Starzonek, Sarah, et al.
Publicado: (2023)

Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression
por: Kemper, Marius, et al.
Publicado: (2021)

Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions
por: Starzonek, Sarah, et al.
Publicado: (2020)

High BCAR1 expression is associated with early PSA recurrence in ERG negative prostate cancer
por: Heumann, Asmus, et al.
Publicado: (2018)

Radiotherapy and chemotherapy change vessel tree geometry and metastatic spread in a small cell lung cancer xenograft mouse tumor model
por: Frenzel, Thorsten, et al.
Publicado: (2017)

Heterogeneity of Estrogen Receptor Expression in Circulating Tumor Cells from Metastatic Breast Cancer Patients
por: Babayan, Anna, et al.
Publicado: (2013)

Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer
por: Kluth, Martina, et al.
Publicado: (2017)

Deletion of 8p is an independent prognostic parameter in prostate cancer
por: Kluth, Martina, et al.
Publicado: (2016)

A pre-specified model based on four kallikrein markers in blood improves predictions of adverse pathology and biochemical recurrence after radical prostatectomy
por: Haese, Alexander, et al.
Publicado: (2020)

SDA, a DNA Aptamer Inhibiting E- and P-Selectin Mediated Adhesion of Cancer and Leukemia Cells, the First and Pivotal Step in Transendothelial Migration during Metastasis Formation
por: Faryammanesh, Rassa, et al.
Publicado: (2014)

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape
por: Mohme, Malte, et al.
Publicado: (2020)

A nuclear shift of GSK3β protein is an independent prognostic factor in prostate cancer
por: Eichenauer, Till, et al.
Publicado: (2019)

Upregulation of the heterogeneous nuclear ribonucleoprotein hnRNPA1 is an independent predictor of early biochemical recurrence in TMPRSS2:ERG fusion-negative prostate cancers
por: Möller, Katharina, et al.
Publicado: (2020)

Epithelial splicing regulatory protein 1 and 2 (ESRP1 and ESRP2) upregulation predicts poor prognosis in prostate cancer
por: Freytag, Morton, et al.
Publicado: (2020)

Liquid biopsy: blood‐based analyses of circulating cell‐free DNA in xenografts
por: Heidrich, Isabel, et al.
Publicado: (2022)

Increased Cytoplasmic CD138 Expression Is Associated with Aggressive Characteristics in Prostate Cancer and Is an Independent Predictor for Biochemical Recurrence
por: Kind, Simon, et al.
Publicado: (2020)

Nuclear ELAC2 overexpression is associated with increased hazard for relapse after radical prostatectomy
por: Schroeder, Cornelia, et al.
Publicado: (2019)

Loss of PSP94 expression is associated with early PSA recurrence and deteriorates outcome of PTEN deleted prostate cancers
por: Luebke, Andreas M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_c50rvcgorkb6q8l5773bnp76mm