Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, and have been clinically used to treat cardiovascular disease. However, a paradoxical increase of reductase protein following statin treatment may attenuate the effect and increase the side effects. He...

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Detalles Bibliográficos
Autores principales: Jiang, Shi-You, Li, Hui, Tang, Jing-Jie, Wang, Jie, Luo, Jie, Liu, Bing, Wang, Jin-Kai, Shi, Xiong-Jie, Cui, Hai-Wei, Tang, Jie, Yang, Fan, Qi, Wei, Qiu, Wen-Wei, Song, Bao-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277434/
https://www.ncbi.nlm.nih.gov/pubmed/30510211
http://dx.doi.org/10.1038/s41467-018-07590-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277434/
https://www.ncbi.nlm.nih.gov/pubmed/30510211
http://dx.doi.org/10.1038/s41467-018-07590-3

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