Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy

Human epidermal growth factor receptor 2 (HER2) gene amplification and/or protein overexpression in tumors is a prerequisite for initiation of trastuzumab therapy. Although HER2 is a cell membrane receptor, differential rates of endocytosis and recycling engender a dynamic surface pool of HER2. Sinc...

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Detalles Bibliográficos
Autores principales: Pereira, Patrícia M. R., Sharma, Sai Kiran, Carter, Lukas M., Edwards, Kimberly J., Pourat, Jacob, Ragupathi, Ashwin, Janjigian, Yelena Y., Durack, Jeremy C., Lewis, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277446/
https://www.ncbi.nlm.nih.gov/pubmed/30510281
http://dx.doi.org/10.1038/s41467-018-07608-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277446/
https://www.ncbi.nlm.nih.gov/pubmed/30510281
http://dx.doi.org/10.1038/s41467-018-07608-w

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