Osthole Synergizes With HER2 Inhibitor, Trastuzumab in HER2-Overexpressed N87 Gastric Cancer by Inducing Apoptosis and Inhibition of AKT-MAPK Pathway

Background and Purpose: Although trastuzumab has shown considerable activity in the treatment of HER2-positive breast and gastric cancers, a significant proportion of patients do not respond to trastuzumab. Recent studies revealed that osthole, an active coumarin isolated from Cnidium monnieri (L.)...

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Detalles Bibliográficos
Autores principales: Yang, Yun, Ren, Feng, Tian, Ziyin, Song, Wei, Cheng, Binfeng, Feng, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277458/
https://www.ncbi.nlm.nih.gov/pubmed/30538636
http://dx.doi.org/10.3389/fphar.2018.01392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277458/
https://www.ncbi.nlm.nih.gov/pubmed/30538636
http://dx.doi.org/10.3389/fphar.2018.01392

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