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Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation
The DNA damage-activated protein kinase Chk1 is known to undergo auto-phosphorylation, however the sites and functional significance of this modification remain poorly understood. We have identified two novel Chk1 auto-phosphorylation sites, threonines 378 and 382 (T378/382), located in a highly con...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277497/ https://www.ncbi.nlm.nih.gov/pubmed/30510197 http://dx.doi.org/10.1038/s41598-018-35616-9 |