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Chk1 KA1 domain auto-phosphorylation stimulates biological activity and is linked to rapid proteasomal degradation

The DNA damage-activated protein kinase Chk1 is known to undergo auto-phosphorylation, however the sites and functional significance of this modification remain poorly understood. We have identified two novel Chk1 auto-phosphorylation sites, threonines 378 and 382 (T378/382), located in a highly con...

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Detalles Bibliográficos
Autores principales:	Gong, Eun-Yeung, Hernández, Beatriz, Nielsen, Jessica Hernández, Smits, Veronique A. J., Freire, Raimundo, Gillespie, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277497/ https://www.ncbi.nlm.nih.gov/pubmed/30510197 http://dx.doi.org/10.1038/s41598-018-35616-9

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