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Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets
Traditionally, small-molecule or antibody-based therapies against human diseases have been designed to inhibit the enzymatic activity or compete for the ligand binding sites of pathological target proteins. Despite its demonstrated effectiveness, such as in cancer treatment, this approach is often l...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Korean Society for Molecular and Cellular Biology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277563/ https://www.ncbi.nlm.nih.gov/pubmed/30486612 http://dx.doi.org/10.14348/molcells.2018.0372 |