Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes

Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibits phosphorylation of RIPK1. RIPK1 regulates inflammation and cell death by interacting with receptor-interacting serine/threonine protein kinases 3(RIPK3). We hypoth...

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Detalles Bibliográficos
Autores principales: Liang, Shuang, Lv, Zheng-tao, Zhang, Jia-ming, Wang, Yu-ting, Dong, Yong-hui, Wang, Zheng-gang, Chen, Kun, Cheng, Peng, Yang, Qing, Guo, Feng-jing, Lu, Wei-wei, Zhu, Wen-tao, Chen, An-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277802/
https://www.ncbi.nlm.nih.gov/pubmed/30542285
http://dx.doi.org/10.3389/fphar.2018.01378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277802/
https://www.ncbi.nlm.nih.gov/pubmed/30542285
http://dx.doi.org/10.3389/fphar.2018.01378

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