Cargando…

Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes

Necrostatin-1 (Nec-1) is a specific small molecule inhibitor of receptor-interacting protein kinase 1 (RIPK1) that specifically inhibits phosphorylation of RIPK1. RIPK1 regulates inflammation and cell death by interacting with receptor-interacting serine/threonine protein kinases 3(RIPK3). We hypoth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Shuang, Lv, Zheng-tao, Zhang, Jia-ming, Wang, Yu-ting, Dong, Yong-hui, Wang, Zheng-gang, Chen, Kun, Cheng, Peng, Yang, Qing, Guo, Feng-jing, Lu, Wei-wei, Zhu, Wen-tao, Chen, An-min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277802/ https://www.ncbi.nlm.nih.gov/pubmed/30542285 http://dx.doi.org/10.3389/fphar.2018.01378

Ejemplares similares

MicroRNA-410-3p modulates chondrocyte apoptosis and inflammation by targeting high mobility group box 1 (HMGB1) in an osteoarthritis mouse model
por: Pan, Hong, et al.
Publicado: (2020)

Hair growth promotion by Necrostatin-1s
por: Zheng, Mei, et al.
Publicado: (2020)

The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis: Nrf2/HMGB1 affects osteoarthritis
por: Li, Wenzhao, et al.
Publicado: (2023)

Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis
por: Tang, Qian, et al.
Publicado: (2017)

Necrostatin-1 protection of dopaminergic neurons
por: Wu, Jing-ru, et al.
Publicado: (2015)

Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications
por: Cao, Liyuan, et al.
Publicado: (2021)

Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin–1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model
por: Wang, Qiwei, et al.
Publicado: (2017)

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease
por: Zhu, S, et al.
Publicado: (2011)

Lycopene inhibits IL‐1β‐induced inflammation in mouse chondrocytes and mediates murine osteoarthritis
por: Zhan, Jingdi, et al.
Publicado: (2021)

Author Correction: Hair growth promotion by Necrostatin-1s
por: Zheng, Mei, et al.
Publicado: (2021)

Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis
por: Jie, Hongyu, et al.
Publicado: (2016)

SCD1 deficiency exacerbates osteoarthritis by inducing ferroptosis in chondrocytes
por: Yu, Chao, et al.
Publicado: (2023)

Inhibition of inflammatory liver injury by the HMGB1-A box through HMGB1/TLR-4/NF-κB signaling in an acute liver failure mouse model
por: Luo, Lidan, et al.
Publicado: (2022)

Toxicity of Necrostatin-1 in Parkinson’s Disease Models
por: Alegre-Cortés, Eva, et al.
Publicado: (2020)

Regulation of Neurogenesis in Mouse Brain by HMGB1
por: Zhao, Xiang, et al.
Publicado: (2020)

The dual role of necrostatin-1 in Parkinson’s disease models
por: Alegre-Cortés, Eva, et al.
Publicado: (2021)

Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice
por: Zhou, Yingqun, et al.
Publicado: (2013)

Necrostatin-1 Synergizes the Pan Caspase Inhibitor to Attenuate Lung Injury Induced by Ischemia Reperfusion in Rats
por: Wang, Liangrong, et al.
Publicado: (2020)

-selectin and SDF-1 enhance the migration of mouse and human cardiac mesoangioblasts
por: Bernal, A, et al.
Publicado: (2012)

Correction: Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
por: Wei, Fangyuan, et al.
Publicado: (2013)

The Anti-inflammatory Effects of HMGB1 Blockades in a Mouse Model of Cutaneous Vasculitis
por: Wang, Jin, et al.
Publicado: (2020)

Effect of necrostatin-1 on sciatic nerve crush injury in rat models
por: Yu, Chen, et al.
Publicado: (2023)

Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway
por: Wei, Fangyuan, et al.
Publicado: (2012)

Glycyrrhizin mitigates radiation‐induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway
por: Zheng, Lei, et al.
Publicado: (2019)

Necrostatin-1 decreases necroptosis and inflammatory markers after intraventricular hemorrhage in mice
por: Liu, Chang, et al.
Publicado: (2022)

Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs
por: Haque, Nazmul, et al.
Publicado: (2020)

RIP1-Dependent and Independent Effects of Necrostatin-1 in Necrosis and T Cell Activation
por: Cho, YoungSik, et al.
Publicado: (2011)

Necrostatin-1 Reduces Neurovascular Injury after Intracerebral Hemorrhage
por: King, Melanie D., et al.
Publicado: (2014)

HMGB1-Promoted and TLR2/4-Dependent NK Cell Maturation and Activation Take Part in Rotavirus-Induced Murine Biliary Atresia
por: Qiu, Yinrong, et al.
Publicado: (2014)

Scutellarin Attenuates the IL-1β-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression
por: Luo, Zucheng, et al.
Publicado: (2020)

Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness
por: Zhang, Lirong, et al.
Publicado: (2019)

MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells
por: Ito, Keisuke, et al.
Publicado: (2017)

Necrostatin-1 Ameliorates Peripheral Nerve Injury-Induced Neuropathic Pain by Inhibiting the RIP1/RIP3 Pathway
por: Liang, Ying-Xia, et al.
Publicado: (2019)

Necrostatin-1 protects C2C12 myotubes from CoCl(2)-induced hypoxia
por: Chen, Rui, et al.
Publicado: (2018)

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer
por: Huang, Kevin Chih-Yang, et al.
Publicado: (2023)

Necrostatin-1 Attenuates Cisplatin-Induced Nephrotoxicity Through Suppression of Apoptosis and Oxidative Stress and Retains Klotho Expression
por: Ning, Yichun, et al.
Publicado: (2018)

Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop
por: Liang, Shuang, et al.
Publicado: (2019)

Alcohol Induces Zebrafish Skeletal Muscle Atrophy through HMGB1/TLR4/NF-κB Signaling
por: Wen, Wei, et al.
Publicado: (2022)

Flow control effect of necrostatin-1 on cell death of the NRK-52E renal tubular epithelial cell line
por: Luo, Jialun, et al.
Publicado: (2017)

Necrostatin-1 Alleviates Bleomycin-Induced Pulmonary Fibrosis and Extracellular Matrix Expression in Interstitial Pulmonary Fibrosis
por: Mou, Fanghong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5jfgttrmbv79tgnhdt4eft1cna